Welcome to the Harvard Digestive Diseases Center

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The Harvard Digestive Disease Center (HDDC) is a community of scientists focused on understanding the cellular, immune, and microbial biology of mucosal surfaces lining the alimentary tract.

We have a major focus on the inflammatory and non-inflammatory diseases of the stomach, intestine, and colon; on basic tissue and organ physiology; and on the gut microbiome and its interface with the host including effects on metabolism.

Center members research addresses four major themes that are basic to understanding the mechanisms of normal digestive tract function and the pathogenesis of disease:

  • Cell, Developmental, and Stem Cell Biology of the Alimentary Tract
  • Innate and Adaptive Mucosal Immunology and Microbial Pathogenesis
  • Microbiome and Metabolism Clinical
  • Translational Research on the Alimentary Tract

The HDDC supports basic and clinical research through Biomedical CoresClinical Research ResourcesEnrichment Events, and Pilot-Feasibility Grants.

Our overarching mission is to foster better translational and basic science in fields related to digestive tract function and digestive diseases by *Connecting People, *Creating Opportunity, and *Extending Resources


Please remember to acknowledge the Harvard Digestive Disease Center and NIH grant P30DK034854 in all publications and presentations emerging from HDDC core services, resources, technology, and expertise.