Biomedical CORE B: Microscopy and Histopathology
- Histology (Paraffin and Frozen Sections)
- Electron and Confocal Microscopy
- Photodocumentation and Widefield Microscopy
- Advanced Imaging Technologies (Lightsheet, STED, SIM, etc.)
- Image Analysis
- Immunohistochemistry and Immunocytochemistry
- Histopathological Analysis (Human and Mouse)
- Consultation and Training
Biomedical CORE C: Epithelial Cell and Mucosal Immunology
- Flow Cytometry Analysis of Cultured Cells or Tissue/Organoid-Derived Cells
- Single Cell Transcriptomics and Bioinformatics
- Spatially Resolved Transcriptomics and Bioinformatics
- Gastrointestinal Organoid Derivation and Culture
- Intestinal Organoid Conditioned Media
- Metabolic and Functional Analysis of Live Cells
Biomedical CORE D: Gnotobiotics, Microbiology, Metagenomics, and Metabolism
- Nucleic Acid Extraction/Amplification
- Microbiome and Microbial Genome Sequencing
- Microbiology
- Gnotobiotic Mice, Hosing, Defined and Complex Associations
- Computation and Data Analysis
- Metabolic Cages and Monitoring, under Conventional and GF States
Clinical Translational Research Program (CTRP)
- Design of Clinical and Preclinical Studies
- Access to Bio-Repository and Data Registry for Human Material
- Statistical Analysis
- Data Interpretation and Presentation
Who can use the HDDC Cores and Services?
Please remember to acknowledge the Harvard Digestive Disease Center and NIH grant P30DK034854 in all publications and presentations emerging from HDDC core services, resources, technology, and expertise.